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Re: Melatonin Users - downregulation?

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To: Public Netbase NewsAgent
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Subject: Re: Melatonin Users - downregulation?
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From: keving@primenet.com (Kevin Goldstein)
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Date: Sat, 29 Jun 1996 17:47:37 -0700 (PDT)
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Article: misc.health.alternative.76248
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Score: 100

Steve Farmer <safarmer@aimnet.com> wrote:
>Jason Taylor wrote, re melatonin production:
>>
>> eroth@data.att.com wrote:
>>
>> : In article q2q@Vir.com, nexus@Vir.com (Alan Pollock) writes:
>> : >Actually, according to multitudinous medline reports and from other
>> : >sources, the pineal gland does Not loose the capacity to produce
>> : >melatonin, nor does it ever stop producing it whilst supplements
> are [being given].
>>
>> That's great news if true! I'm a sceptic at heart though, so would
>> you be so kind as to post the references of the papers which show that
>> production is independent of serum levels? Many thanks in advance.
>I agree with Jason. I've used time-release melatonin (1.8 - 2 mg/night)
>for over a year now. I developed signs of tolerance after a few months.
>I now use melatonin every *other* night, and so far the strategy has
>worked perfectly, at least so far as sleep quality goes. (What all this
>means in regard to melatonin's putative anti-aging properties is an open
>question). If I try to use melatonin every night, my sleep tends to be
>fitful. The same thing happens if I double the dosage.
Every other night and it works OK, double the dosage and it doesn't.
Then the logical thing to try would be *halving* the dosage, but
taking it every night.
-Kevin Goldstein
kg@kg.com
* snip *
>Steve Farmer



